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At Pfizer Oncology Together™, patient support is at the core of everything we do. We’ve gathered resources and developed tools to help patients and their loved ones throughout TALZENNA treatment. From helping to identify financial assistance options to connecting patients to resources for emotional support, your patients’ needs are our priority.
When your patients need support for their day-to-day challenges, we want to be a place they can turn to for help. At Pfizer Oncology Together, our Care Champions, who have social work experience, can connect patients prescribed TALZENNA to resources that may help with some of their daily needs.*
We can connect patients to diagnosis-specific support groups, an independent organization that offers short-term counseling, and a free app, developed by Pfizer Oncology, to help patients connect with loved ones and ask for the support they need
To help support patients’ overall health and well-being, we’ve created resources about physical and mental health, as well as nutritional tips and healthy recipes developed in partnership with dietitians who specialize in oncology nutrition. We can also provide patients with information to help them understand their prescribed TALZENNA
If patients need assistance with transportation or lodging for treatment-related appointments, we’ll connect them to independent organizations that offer these services for free to qualifying patients
And if your patients are leaving work for a period of time during treatment, or preparing to return to work, we can send them information to help make the transition easier
Pfizer Oncology Together can help patients understand their benefits and connect them with financial assistance resources, regardless of their insurance coverage.
Resources for eligible commercial, private, employer, and state health insurance marketplace patients:
Co-pay assistance: Eligible, commercially insured patients may pay as little as $0 per month,† regardless of income. There are no income requirements, forms, or faxing to enroll
For more information, see your Pfizer Oncology representative, or visit www.PfizerOncologyTogether.com.
Help identifying resources for eligible patients with Medicare/Medicare Part D, Medicaid, and other government insurance plans:
Help identifying resources for eligible patients without any form of healthcare coverage:
If patients prescribed TALZENNA need access or reimbursement support, Pfizer Oncology Together is here to help with:
We can help determine a patient’s coverage and out-of-pocket costs
We can coordinate with a patient's insurer to determine the PA requirements. After your office submits a PA request, we'll follow up with the payer until a final outcome is determined.
We can help you and your office staff understand the payer requirements as you prepare an appeal submission. After your office submits an appeal, we’ll follow up with the payer to track its progress until a final outcome is determined.
To help patients access the medication you’ve prescribed, we can identify specialty pharmacy options. If you prefer, you and your staff can also continue to work directly with specialty pharmacies.
Pfizer Oncology Account Specialists can provide detailed information on Pfizer Oncology medications and access resources. In addition, they can help you and your office staff contact a Pfizer Oncology Field Reimbursement Manager (FRM) in your area.
FRMs are trained to help address specific access issues—in person or over the phone. They can help educate your staff on our access and reimbursement resources and help address challenging or urgent Pfizer Oncology patient cases you have sent to Pfizer Oncology Together.
Pfizer Oncology together™ provides personalized support and financial assistance resources to help patients access their prescribed Pfizer Oncology medications.
Call 1-877-774-5675 (Monday – Friday 8am – 8pm ET)
Learn about the guidelines for gBRCA testing
The safety of TALZENNA was evaluated in an open-label, 2:1 randomized Phase 3 study1,3
The recommended starting dose of TALZENNA is 1 mg taken orally once daily1
To report an adverse event, please call 1-800-438-1985
Pfizer for Professionals 1-800-505-4426
This site is intended only for U.S. healthcare professionals. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only.
© 2024 Pfizer Inc. All rights reserved.
TALZENNA is indicated as a single agent for the treatment of adult patients with deleterious or suspected deleterious germline breast cancer susceptibility gene (BRCA)-mutated (gBRCAm) human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer. Select patients for therapy based on an FDA-approved companion diagnostic for TALZENNA.
Myelodysplastic Syndrome/Acute Myeloid Leukemia (MDS/AML), including cases with a fatal outcome, has been reported in patients who received TALZENNA. Overall, MDS/AML has been reported in 0.4% (3 out of 788) of solid tumor patients treated with TALZENNA as a single agent in clinical studies. The duration of TALZENNA treatment in these three patients prior to developing MDS/AML was 4 months, 24 months, and 60 months respectively. These patients had received previous chemotherapy with platinum agents and/or other DNA damaging agents including radiotherapy. Monitor patients for hematological toxicity and discontinue if MDS/AML is confirmed.
Myelosuppression consisting of anemia, neutropenia, and/or thrombocytopenia have been reported in patients treated with TALZENNA. Grade ≥3 anemia, neutropenia, and thrombocytopenia were reported, respectively, in 39%, 21%, and 15% of patients receiving TALZENNA as a single agent. Discontinuation due to anemia, neutropenia, and thrombocytopenia occurred, respectively, in 0.7%, 0.3%, and 0.3% of patients.
Withhold TALZENNA until patients have adequately recovered from hematological toxicity caused by previous therapy. Monitor blood counts monthly during treatment with TALZENNA. If hematological toxicities do not resolve within 28 days, discontinue TALZENNA and refer the patient to a hematologist for further investigations including bone marrow analysis and blood sample for cytogenetics. If MDS/AML is confirmed, discontinue TALZENNA.
TALZENNA can cause fetal harm when administered to pregnant women. Advise women of reproductive potential to use effective contraception during treatment and for 7 months following the last dose of TALZENNA. Verify pregnancy status in females of reproductive potential prior to initiating TALZENNA treatment. Advise male patients with female partners of reproductive potential or who are pregnant to use effective contraception during treatment with TALZENNA and for 4 months after receiving the last dose. Based on animal studies, TALZENNA may impair fertility in males of reproductive potential. Advise women not to breastfeed while taking TALZENNA and for 1 month after receiving the last dose because of the potential for serious adverse reactions in a breastfed child.
Serious adverse reactions of TALZENNA occurred in 32% of patients. Serious adverse reactions reported in >2% of patients included anemia (6%) and pyrexia (2%). Fatal adverse reactions occurred in 1% of patients, including cerebral hemorrhage, liver disorder, veno-occlusive liver disease, and worsening neurological symptoms (1 patient each).
The most common (≥20%) adverse reactions of any grade for TALZENNA vs chemotherapy, including laboratory abnormalities, were hemoglobin decreased (90% vs 77%), neutrophils decreased (68% vs 70%), lymphocytes decreased (76% vs 53%), platelets decreased (55% vs 29%), fatigue (62% vs 50%), glucose increased (54% vs 51%), aspartate aminotransferase increased (37% vs 48%), alkaline phosphatase increased (36% vs 34%), alanine aminotransferase increased (33% vs 37%), calcium decreased (28% vs 16%), nausea (49% vs 47%), headache (33% vs 22%), vomiting (25% vs 23%), alopecia (25% vs 28%), diarrhea (22% vs 26%), and decreased appetite (21% vs 22%).
Clinically relevant adverse reactions in <20% of patients who received TALZENNA included abdominal pain (19%), dizziness (17%), dysgeusia (10%), dyspepsia (10%), stomatitis (8%), and febrile neutropenia (0.3%).
Effect of P-gp Inhibitors: Avoid coadministration of TALZENNA with the following P-gp inhibitors: itraconazole, amiodarone, carvedilol, clarithromycin, itraconazole, and verapamil. If coadministration of TALZENNA with these P-gp inhibitors cannot be avoided, reduce the dose of TALZENNA. When the P‑gp inhibitor is discontinued, increase the dose of TALZENNA. Coadministration of TALZENNA with these P‑gp inhibitors increased talazoparib concentrations, which may increase the risk of adverse reactions.
Monitor for increased adverse reactions and modify the dosage as recommended for adverse reactions when TALZENNA is coadministered with other P‑gp inhibitors.
Effect of BCRP Inhibitors: Monitor patients for increased adverse reactions and modify the dosage as recommended for adverse reactions when TALZENNA is coadministered with a BCRP inhibitor. Coadministration of TALZENNA with BCRP inhibitors may increase talazoparib exposure, which may increase the risk of adverse reactions.
Reduce the recommended dosage of TALZENNA in patients with moderate (CLcr 30 – 59 mL/min) and severe (CLcr 15 – 29 mL/min) renal impairment. Monitor patients with severe renal impairment for increased adverse reactions and modify the dosage as recommended for adverse reactions. No dose adjustment is recommended for patients with mild renal impairment (CLcr 60 – 89 mL/min). TALZENNA has not been studied in patients requiring hemodialysis.
TALZENNA is indicated as a single agent for the treatment of adult patients with deleterious or suspected deleterious germline breast cancer susceptibility gene (BRCA)-mutated (gBRCAm) human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer. Select patients for therapy based on an FDA-approved companion diagnostic for TALZENNA.